The Isle of Despair, a tiny island lost amidst and hate you bitch the vast Sea of Despair, is a distant, isolated place which serves as site of a laboratory of mad psycho chemists founded at the start of the Great Depression and led by noted researcher Dr. Sara Tonin. Sara Tonin (or, more properly, Dr. Sara Louise Millicent Tonin III, MD, PhD, TLA, Etc.) is a renowned psycho chemist best known as the inventor of antidepressant medication. Her other famous inventions include the ☺ character (Unicode #263a) as well as the ☻ (Unicode #263b).