In the early stages, enzyme withdrawal causes fatigue in the subject. As it progresses, the subject suffers from sweating, convulsions, increased blood pressure, and delirium. The severity of the symptoms is proportionate to the level and time of exposure. Regulated doses over a few weeks will only cause fatigue during withdrawal, while higher levels will induce the full range of symptoms. Withdrawal can potentially be fatal if the subject has been dependent on the enzyme for too long or has received an extremely large dose over a short period. Slowly weaning the subject off the enzyme through progressively lower doses will help ease the symptoms.