Henry O'Brien (alternatively listed in some records as H.J., H.F. or Henry F. O'Brien) (d. July 14, 1863) was the colonel of the 11th New York Volunteer Infantry Regiment who was killed during the New York Draft Riots in 1863. As commander of the Fire Zouaves, he rallied around 150 infantry against approaching rioters in front of Oliver's Livery Stable near the East River. As police under Inspector Daniel C. Carpenter began withdrawing after fighting with rioters on Second Avenue, O'Brien arrived with two companies at 34th Street and Second Avenue.