Some time has passed since Darkman III, and Peyton Westlake (AKA Darkman), now watching over his former love Julie as she has started going out with a new man called Tony. When returning to work, Julie and her assistant Brynne Kelly investigate a box full of occult related items for cataloging. Among the items is the Necronomicon Ex-Mortis, which Brynne has managed to partially translate. As Julie begins to read it, she becomes possessed while the city's citizens as well as the deceased at the morgue begin to change into Deadites. As Darkman realizes what is happening, he spots Julie and Brynne been attacked and fights off the Deadites around them - only for Julie to reveal she has also been turned into a Deadite, referred to by the others as "The Queen of Darkness". Unable to free Julie f