According to the synopsis of the first issue, the story took place between the events of The Curse of the Black Pearl and Dead Man's Chest. "Return to the world of Captain Jack Sparrow in these untold tales of pirate adventure on the high seas! After squaring off with Captain Barbossa in a cursed duel, Jack is back on the run. And while Admiral Norrington may have given Jack a head start on his escape, the chase is now on.”" ―Sypnosis of the first issue