USS Harrison (DD-573) was a Fletcher-class destroyer of the United States Navy. She was second Navy ship of that name, and the first named in honor of Captain Napoleon Harrison (1823–1870). Harrison was launched by Consolidated Steel Corporation, Orange, Tex., 4 May 1942, sponsored by Mrs. Harry B. Hird; and commissioned 25 January 1943, Commander C. M. Dalton in command.