The Siege of Lilybaeum (250 BC) was a battle of the First Punic War that pitted a Roman Consular army led by Gaius Atilius Regulus Serranus and Lucius Manlius Vulso Longus against a Carthaginian army under the command of the general Himilcon. The battle resulted in a Roman retreat from the siege after the destruction of their fleet at Drepana.