Later in 2365, Captain Donald Varley commanded the Yamato. Late that year, the Yamato was destroyed with the loss of all hands in the Romulan Neutral Zone. Her destruction was caused by an Iconian computer virus that had been transmitted to the Yamato by a probe. The virus spread through the ship's systems and eventually caused a failure in the matter/antimatter control systems. (TNG episode: "Contagion")