Helminth is a being residing in the Helminth Infirmary of the Orbiter, the door of which can only be open with Nidus or a Warframe with a fully matured Helminth cyst. Ordis claims that Helminth is responsible for operating the Orbiter's biological functions, and despite his disgust towards it, views Helminth as a "necessary evil". Initially dormant, Helminth can only be awakened after completing The Glast Gambit questline.