Zethes and his brother, Kalais, sailed with Jason on board the Argo. The crew of the Argo was made up of some of the greatest heroes: Heracles, Castor and Polydeuces, Atalanta, Meleager, and Orpheus. Before setting sail to retrieve The Golden Fleece from Colchis, the crew offered a sacrifice to Apollo. Upon return to Greece, the what seemed to be massive crew's numbers dwindled leaving only a few, and mostly women. Zethes father offered Zethes and Calais immortality, like his daughter goddess, Khione, and they guarded the God of the North Wind's palace for more than a millennium.