The 2000 Hamilton Tiger-Cats season was the 43rd season for the team in the Canadian Football League and their 51st overall. The Tiger-Cats finished in 2nd place in the East division with a 9–9–0–2 record in the first CFL season that awarded points to overtime losses. The Tiger-Cats failed to defend their Grey Cup title when they lost to the Winnipeg Blue Bombers in the East Semi-Final.