In 2154, the warp matrix of the Enterprise NX-01 was compromised by a Klingon subroutine. It infiltrated the ship's command protocols to do so. (ENT: "Affliction") In late 2375, Noah Lessing of the USS Equinox designed a subroutine to mask the internal sensors of the USS Voyager, allowing the Equinox crew to steal a modified field generator that provided protection against nucleogenic lifeforms. (VOY: "Equinox")