The 2010 Louisville Cardinals football team represented the University of Louisville in the 2010 NCAA Division I FBS college football season. The Cardinals were led by head coach Charlie Strong, who was in his 1st season. They played their home games at Papa John's Cardinal Stadium and were members of the Big East Conference. They finished the season 7–6, 3–4 in Big East play and were invited to the Beef 'O' Brady's Bowl St. Petersburg where they defeated Southern Miss 31–28.