Karate Blazers is a beat-em-up, martial arts fighting game with four main characters: mercenary Mark, wrestler Glen, "mysterious fighter" Gill, and ninja Akira. The plot is a common one for Video System: a girl has been kidnapped, and the player has to save her. Both Glen and Gill appear later as the Blazers in Sonic Wings 3, where they will again try to rescue their master's daughter and the stolen scrolls.