Santiago de Guayaquil, or just Guayaquil; Spanish: Guayaquil, IPA: , is the largest and the most populous city in Ecuador, as well as that nation's main sea port. Guayaquil is on the west margin of the Guayas River, which flows into the Gulf of Guayaquil in the Pacific Ocean. Guayaquil is at 2.21°S 79.90°W, about 250 km south-southwest of the capital of Ecuador, Quito. According to the most recent census (2001), its population was 2,285,379. Edit this section or read more