Giovanni Domenico de Cupis (Cupi, Cuppi) (1493-1553) was an Italian Cardinal, created by Pope Leo X in the consistory of July 1, 1517. He was Crown-cardinal of Scotland. He was a friend of Ignatius Loyola. His mother was Lucrezia Normanni, who had had a daughter Felice della Rovere by Pope Julius II before marrying Bernardino de Cupis, Giovanni Domenico's father. He owed early advancement as Bishop of Trani to Julius. He was Bishop of Albano in 1531, Bishop of Sabina in 1532, Bishop of Porto e Santa Rufina in 1535 and Bishop of Ostia in 1537. Dean of the College of Cardinals in 1541.