The Edyrem were the next generation of the Nephalem and were normal people until converted by Uldyssian. Uldyssian awakened their latent powers, and fought beside them in the Sin War. The main goals of the Edyrem were to bring the Triune and the Cathedral of Light to justice, and despite sustaining heavy losses, they eventually defeated both Lilith and the Veiled Prophet Inarius. Breaking both's power and influence over humankind; perhaps forever.