The show revolves around a corporation running numerous underground establishments (known as "Dollhouses") across the globe which program individuals referred to as Actives (or Dolls) with temporary personalities and skills. Wealthy clients hire Actives from Dollhouses at great expense for various purposes. The series primarily follows the Active known as Echo, played by Eliza Dushku, on her journey towards self-awareness. Dushku also served as series producer.