USS Spruance (DD-963) was the lead ship of the Spruance-class of destroyers in the United States Navy. She was named for Admiral Raymond A. Spruance. Spruance was built by the Ingalls Shipbuilding Division of Litton Industries at Pascagoula, Mississippi, and launched by Mrs. Raymond A. Spruance, Commander Raymond J. Harbrecht in command. Spruance served in the U.S. Atlantic Fleet, assigned to Destroyer Squadron 24 and operating out of Naval Station Mayport, Florida. She was decommissioned on 23 March 2005 and then was sunk as a target on 8 December 2006.