The Devil Horns appears in Dead Space 3 as the most powerful weapon in the game, unlocked after completing the game on Classic Mode in New Game+. Similar to the Hand Cannon in Dead Space 2. It is a (mostly) one-shot kill weapon, with the main function being "Bang!" and the alt-fire being "Pew Pew!". When reloading, Isaac will perform a "rocking out" animation, and a metal guitar riff will play.