Giovanni was born at Mirandola, near Modena, the youngest son of Francesco I, Lord of the Mirandola and Count of Concordia (1415–1467), by his wife Giulia, daughter of Feltrino Boiardo, Count di Scandiano. The family had long dwelt in the Castle of Mirandola (Duchy of Modena), which had become independent in the fourteenth century and had received in 1414 from the Emperor Sigismund the fief of Concordia.The Mirandola was a small province in the region of Emilia-Romagna near Ferrara, but the Pico dynasty ruled it as independent sovereigns rather than as noble vassals, gradually aggrandizing power in northern Italy. The Pico della Mirandola were closely related to the Sforza, Gonzaga and Este dynasties, and Giovanni's siblings wed the scions of the hereditary rulers of Corsica, Ferrara, Bolo