In the season five episode The Cutie Re-Mark - Part 2, Dr. Horse appears as a resident of Zecora's secret camp in the Everfree Forest, hiding from the changelings. When Queen Chrysalis appears to attack the camp, Dr. Horse flees in terror when a filly next to him is revealed to be a changeling. In season seven, Dr. Horse briefly appears in A Flurry of Emotions as a doctor at Ponyville Hospital. In A Health of Information, he diagnoses Zecora's Swamp Fever and later comes down with the disease himself.