The plot concerns high school student Amy Smootster, and her attempts to start a relationship with her guidance counselor Tim. Another plot thread follows her relationship with circles and squares---it seems that circular objects tend to help or defend her, while squares try to hurt her. All of this has something to do with her feet producing copious but never-defined fluid when she feels shame. There was a five-issue follow-up story, set fifteen years later, called Zero Girl: Full Circle, which put Amy and Tim in the background and focused on Tim's daughter, Nikki.