The earliest archaeological evidence of medieval life at the place is a grave with a few coins and decorations from the time of Byzantine Emperor Michael VIII Palaiologos (1259–1282). Some other items also date to the 13th century while the marble frieze above the central gate of the church dates to the 13th or 14th century. A couple of new buildings were constructed in the monastery at the time of Despot Alexius Slav. The earliest written source testifying to the monastery's existence is a note on a chant book from 1551, today in the Great Lavra library on Mount Athos.