The third USS Macdonough (DD-351) was a Farragut-class destroyer in the United States Navy during World War II. She was named for Thomas Macdonough. Macdonough was laid down 15 May 1933 by the Boston Navy Yard; launched 22 August 1934; sponsored by Miss Rose Shaler Macdonough, granddaughter of Commodore Thomas Macdonough; and commissioned 15 March 1935, Commander Charles S. Alden in command.