Janine Valentine was created in a freak accident back in 1990 while the Umbrella Corporation was creating Jane Valentine, a clone of Jill Valentine. She was accidently made when DNA from Jane accidently ended up in a vial of the T-Virus and soon after the growing process, this clone went mad, broke out of her Cloning Tube and then killed everyone in the lab. After observing this, Albert Wesker gave her a purpose in Umbrella and kept her secret, as well as held captive until 2037 when she escaped from her prison and was roaming free in New Raccoon City.